Human-human haptic collaboration in cyclical Fitts' tasks

Understanding how humans assist each other in haptic interaction teams could lead to improved robotic aids to solo human dextrous manipulation. Inspired by experiments reported in Reed et al. (2004), which suggested two-person haptically interacting teams could achieve a lower movement time (MT) than individuals for discrete aiming movements of specified accuracy, we report that two-person teams (dyads) can also achieve lower MT for cyclical, continuous aiming movements. We propose a model, called endpoint compromise, for how the intended endpoints of both subjects' motion combine during haptic interaction; it predicts a ratio of /spl radic/2 between slopes of MT fits for individuals and dyads. This slope ratio prediction is supported by our data

Control System Analysis and Synthesis via Linear Matrix Inequalities

A wide variety of problems in systems and control theory can be cast or recast as convex problems that involve linear matrix inequalities (LMIs). For a few very special cases there are "analytical solutions" to these problems, but in general they can be solved numerically very efficiently. In many cases the inequalities have the form of simultaneous Lyapunov or algebraic Riccati inequalities; such problems can be solved in a time that is comparable to the time required to solve the same number of Lyapunov or Algebraic Riccati equations. Therefore the computational cost of extending current control theory that is based on the solution of algebraic Riccati equations to a theory based on the solution of (multiple, simultaneous) Lyapunov or Riccati inequalities is modest. Examples include: multicriterion LQG, synthesis of linear state feedback for multiple or nonlinear plants ("multi-model control"), optimal transfer matrix realization, norm scaling, synthesis of multipliers for Popov-like analysis of systems with unknown gains, and many others. Full details can be found in the references cited

Using Ground Transportation for Aviation System Disruption Alleviation

An investigation was made into whether passenger delays and airline costs due to disruptive events affecting European airports could be reduced by a coordinated strategy of using alternative flights and ground transportation to help stranded passengers reach their final destination using airport collaborative decision-making concepts. Optimizing for airline cost for hypothetical disruptive events suggests that, for airport closures of up to 10 h, airlines could benefit from up to a 20% reduction in passenger delay-related costs. The mean passenger delay could be reduced by up to 70%, mainly via a reduction in very long delays

Flexible operation of CSIRO's post-combustion CO2 capture pilot plant at the AGL Loy Yang power station

Flexible operation has the potential to significantly improve the economic viability of post-combustion CO2 capture (PCC). However, the impact of disturbances from flexible operation of the PCC process is unclear. The purpose of this study was to investigate the effects of flexible operation in a PCC pilot plant by implementing step-changes for improved dynamic data reliability. The flexible operation campaign was conducted at the CSIRO PCC pilot plant at AGL Loy Yang using monoethanolamine (MEA) absorbent. The pilot plant was operated under a broad range of transient conditions (changing flue gas flow, liquid absorbent flow and steam pressure) to capture the dynamics of a PCC process during flexible operation. The study demonstrated that the dynamics of flue gas flow rate was faster than absorbent flow rate. The greatest CO2 removal% was achieved at the lowest flue gas flow rate or at the highest absorbent flow rate; however, the latter provided improved energy efficiency. The steam pressure parameter could adjust the temperature of all columns simultaneously which can be used to compensate for effects from ambient conditions or heat losses. These results verify the technical feasibility of flexible PCC operation and provide a suitable dataset for dynamic model validation

Statistically designed experiments to screen chemical mixtures for possible interactions.

For the accurate analysis of possible interactive effects of chemicals in a defined mixture, statistical designs are necessary to develop clear and manageable experiments. For instance, factorial designs have been successfully used to detect two-factor interactions. Particularly useful for this purpose are fractionated factorial designs, requiring only a fraction of all possible combinations of a full factorial design. Once the potential interaction has been detected with a fractionated design, a more accurate analysis can be performed for the particular binary mixtures to ensure and characterize these interactions. In this paper this approach is illustrated using an in vitro cytotoxicity assay to detect the presence of mixtures of Fusarium mycotoxins in contaminated food samples. We have investigated interactions between five mycotoxin species (Trichothecenes, Fumonisins, and Zearalenone) using the DNA synthesis inhibition assay in L929 fibroblasts. First, a central composite design was applied to identify possible interactive effects between mycotoxins in the mixtures (27 combinations from 5(5) possible combinations). Then two-factor interactions of particular interest were further analyzed by the use of a full factorial design (5 x 5 design) to characterize the nature of those interactions more precisely. Results show that combined exposure to several classes of mycotoxins generally results in effect addition with a few minor exceptions indicating synergistic interactions. In general, the nature of the interactions characterized in the full factorial design was similar to the nature of those observed in the central composite design. However, the magnitude of interaction was relatively small in the full factorial design

The effect of a preoperative subconjuntival injection of dexamethasone on blood-retinal barrier breakdown following scleral buckling retinal detachment surgery: a prospective randomized placebo-controlled double blind clinical trial

Background: Blood-retinal barrier breakdown secondary to retinal detachment and retinal detachment repair is a factor in the pathogenesis of proliferative vitreoretinopathy (PVR). We wished to investigate whether an estimated 700 to 1000 ng/ml subretinal dexamethasone concentration at the time of surgery would decrease the blood-retinal barrier breakdown postoperatively. Methods: Prospective, placebo-controlled, double blind clinical trial. In 34 patients with rhegmatogenous retinal detachment scheduled for conventional scleral buckling retinal detachment surgery, a subconjunctival injection of 0.5 ml dexamethasone diphosphate (10 mg) or 0.5 ml placebo was given 5-6 hours before surgery. Differences in laser flare photometry (KOWA) measurements taken 1, 3 and 6 weeks after randomisation between dexamethasone and placebo were analysed using mixed model ANOVA, while correcting for the preoperative flare measurement. Results: Six patients did not complete the study, one because of recurrent detachment within 1 week, and five because they missed their postoperative laser flare visits. The use of dexamethasone resulted in a statistically significant decrease in laser flare measurements at the 1-week postoperative visit. Conclusion: The use of a preoperative subconjunctival injection of dexamethasone decreased 1-week postoperative blood-retina barrier breakdown in patients undergoing conventional scleral buckling retinal detachment surgery. This steroid priming could be useful as a part of a peri-operative regime that would aim at decreasing the incidence of PVR

The intensity paradox:A systematic review and meta‐analysis of its impact on the cardiorespiratory fitness of older adults

Aim: The present systematic review and meta‐analysis aimed to compare the effect of moderate‐ versus high‐intensity aerobic exercise on cardiorespiratory fitness (CRF) in older adults, taking into account the volume of exercise completed. Methods: The databases MEDLINE (Ovid), EMBASE (Ovid), and CENTRAL (Cochrane Library) were searched to identify randomized controlled trials (RCTs). Two reviewers extracted data and assessed bias. Comprehensive Meta‐Analysis software calculated overall effect size, intensity differences, and performed meta‐regression analyses using pre‐to‐post intervention or change scores of peak oxygen uptake (V̇O2peak). The review included 23 RCTs with 1332 older adults (intervention group: n = 932; control group: n = 400), divided into moderate‐intensity (435 older adults) and high‐intensity (476 older adults) groups. Results: Meta‐regression analysis showed a moderate, but not significant, relationship between exercise intensity and improvements in V̇O2peak after accounting for the completed exercise volume (β = 0.31, 95% CI = [−0.04; 0.67]). Additionally, studies comparing moderate‐ versus high‐intensity revealed a small, but not significant, effect in favor of high‐intensity (Hedges' g = 0.20, 95% CI = [−0.02; 0.41]). Finally, no significant differences in V̇O2peak improvements were found across exercise groups employing various methods, modalities, and intensity monitoring strategies. Conclusion: Findings challenge the notion that high‐intensity exercise is inherently superior and indicate that regular aerobic exercise, irrespective of the specific approach and intensity, provides the primary benefits to CRF in older adults. Future RCTs should prioritize valid and reliable methodologies for monitoring and reporting exercise volume and adherence among older adults